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CDO Services
01
Transient expression system을 이용한 단백질의약품 생산
  • 후보물질 발현 확인
  • 단백질의약품 생산 및 분석
02
CHO-DG44, CHO-K1을 이용한 고발현 생산세포주 개발
  • Transfection, selection, amplification, single cell cloning, clone evaluation and RCB banking
  • 생산세포주를 이용한 단백질의약품 생산 및 분석
  • 세포주 장기안정성 평가
Transient CLD Flow :
about 1 month
(Including host cell expansion)
  • Transfect CHO host cell with vector Transfect CHO host cell with vector
  • Production
Stable CLD Flow :
about 9 months
  • Transfect CHO host cell with vector Transfect CHO host cell with vector
  • Select with
    expression system or
    antibiotics
  • Gene amplification
  • Pool evaluation Pool evaluation (Biological activity etc.)
  • Gain high producing pool
    (FACS sorter)
  • Single cell cloning Single cell cloning
  • RCB candidate selection
    (Top 3)
  • Long term stability
    (Growth profile, Productivity,
    Biological activity etc.)
  • RCB selection (1 Lead + 2 back-up) RCB selection (1 Lead + 2 back-up)